The objective is to provide bioengineering students with a quantitative understanding of the biomechanical properties of hard and soft human tissues from physiological and pathological aspects. In this course, we will introduce the fundamental principles in solid mechanics and fluid mechanics and the methods of assessment to quantify the biomechanical properties of these human tissues. We will also describe the normal tissue functions, characteristic changes of material properties due to certain pathological conditions, and current non-surgical and surgical treatments for correction. In selected lectures, guest speakers (clinicians and surgeons) will be invited to introduce historical and current treatments options. Students are expected to lead provide critical reviews on current challenges and novel developments in selected topics